LOUISE BRENNAN

Louise joined us in September 2023 after completing a very successful PhD with Dr Richard Mort at Lancaster University where she researched cilia biology.

Publications:

​Wilkinson EL*, Brennan LC*, …, Allinson SL, Jackson IJ,  Mort RL. Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage. (2022). Pigment Cell & Melanoma Research, 36(1), pp. 71–77. 

Eckl KM, Gruber R, Brennan LC, …, Schmuth M. Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V. (2021). Frontiers in Genetics, 12, p. 1227

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Since joining our group Louise has been able to build a strong portfolio of work including

1. Being the first to describe the role of SYCP1 in cancer

LC Brennan, OV Grinchuk, M Pachon, IF Sou, CJ Fawcett, CG Nogueira, M Guthrie, AD Bates, M Hine, A Thomaz, Z Hu, AB Fielding, OR Davies, W-W Tee, UL McClurg (2025) Moonlighting Role of Meiotic SYCP1 in Breast Cancer: A Chromatin-Bound Regulator of DNA Repair, Transcription, and Drug Resistance. BioRxiv

2. Winning the prize for the best talk at the UK Cilia and Centrosome Meeting 2024

3. Louise has also given oral presentations at multiple prestigious meetings including EMBO Meiosis 2025, British Meiosis Meeting 2024, EMBO Meiosis and Germ Sectorial 2024